野狼社区

New research led by University of 野狼社区 and NIHR 野狼社区 Biomedical Research Centre (BRC) scientists has profiled the side effects of methotrexate 鈥� a common drug used to treat arthritis and other autoimmune diseases.

The authors hope their findings 鈥� published today in journal Rheumatology 鈥� will ease the concerns of patients before commencing treatment, who often lack knowledge of the drug, its impact and side effects.

Though the study is unable to conclude if the drug causes the side effects they report in arthritis patients, the associations give them and their doctors 鈥� valuable information, argue the researchers.

The principle investigator, Dr Suzanne Verstappen from The University of 野狼社区, is supported by Versus Arthritis and 野狼社区 BRC. The BRC鈥檚 aims to use biomarkers such as patient data, to predict outcomes and personalise treatments for patients with MSK conditions. 

The team evaluated data of 1,069 patients who participated in the Rheumatoid Arthritis Medication Study (RAMS) from 38 hospitals across the UK, including in Greater 野狼社区. The patients were recruited to the study before starting methotrexate treatment and were followed up for one year.

At six and 12-months, 957 patients (89.5 per cent) and 902 patients (84.4 per cent) were still taking the drug orally, respectively.

However, 106 (9.9per cent) and 169 (15.8per cent) had switched to subcutaneous methotrexate by six and 12 months respectively.

Side effects were common among patients over the first year of methotrexate, though most were not serious.

Overall, 77.5per cent experienced at least one side effect during the 12 months: 250 reported only one, 169 reported two, and the others reported three or more.

Of the side effects associated with taking the drug:

• 42 per cent were gastrointestinal, including nausea (31per cent) and Diarrhoea (15per cent).
• 39.6 per cent were generalised, including fatigue (29 per cent).
• 28.6 per cent were neurological, including headaches (19 per cent) and dizziness (12 per cent).
• 26.0 per cent were mucocutaneous, including alopecia (9 per cent), and mouth ulcers (12 per cent).

Older age was associated with less reporting of gastrointestinal side effects, whereas women were more likely to report gastrointestinal, mucocutaneous, or neurological side effects compared to men.

Alcohol consumption at the start of treatment was associated with nausea, alopecia, and mucocutaneous side effects while taking the drug. Patients who had higher levels of concern about treatment reported more gastrointestinal side effects, particularly nausea.

PI of the RAMS study, Dr Suzanne Verstappen is a Reader in musculoskeletal epidemiology at The University of 野狼社区 and a researcher for 野狼社区 BRC鈥檚 Adult Inflammatory Arthritis research programme. She said: 鈥淢ethotrexate has transformed the treatment of inflammatory arthritis and improved the lives of almost two  million people worldwide.

鈥淏ut worrying about side effects could stop patients from initiating this important drug, or reduce adherence to treatment.

鈥淭hese findings, however, provide patients and clinicians with insight into the management of patients with rheumatoid arthritis starting methotrexate.

鈥淭heir concerns can be lessened by stressing the benefits of the treatment alongside a more specific discussion about side effects.鈥�

PhD researcher Ahmad Sherbini and first author of the manuscript from The University of 野狼社区, said: 鈥淢ethotrexate is currently the drug of first choice for newly diagnosed patients with rheumatoid arthritis due to its low-cost and established efficacy.

鈥淗owever, side effects associated with it have a considerable impact on treatment retention rates during the first year of treatment.

鈥淯sing the data in this study, patients can make informed decisions whether to start this drug and potentially increasing adherence to treatment.鈥�

鈥淚t can also help identifying patients with higher risk of side effects who require frequent monitoring and additional GP visits. Ultimately and with further studies, treatment can be tailored to patients, and better resource utilisation can be achieved.鈥�

Dr Natalie Carter, Head of Research Engagement at Versus Arthritis said: 鈥淢ethotrexate can be a highly effective treatment in controlling inflammatory arthritis, but for many there can be sides effects and illness which causes worry and distress.

鈥淩esearch like this is vitally important. It means that people with arthritis are better informed on the medications being suggested and can support them when navigating a sometimes confusing and complicated treatment regime, especially when first diagnosed.

鈥淲ith a better understanding on the types of side effects caused by medication people with arthritis can have productive conversations with their rheumatology team about their treatments on what is working, what is not, and how they can tailor that treatment to get the best possible result in managing their condition.鈥�

Image: open bottle of methotrexate drug鈥攆irst used in the early 1950s ()